Content Summary
Peyronie's Disease
According to urologists, about 10% of men have a medium-high curve in the penis. However, peyronie’s disease or acquired curvature of the penis affects less than 5% of men.
This disease of unknown origin causes a fibrous band in the corpora cavernosa of the penis. These hardened areas lead to a curve in the erect penis. Erections can be painful and, depending on the degree of the curve, can prevent penetration, causing serious damage to the sexual health of the patient.
Fibrotic plaques in Peyronie’s disease 01
Fibrotic plaques in Peyronie’s disease 02
Treatments in our Andromedi Clinics in Madrid, Seville and the Canary Islands.
Despite being a fairly widespread disease, so far the common treatment is surgery to correct the curve, usually by plication techniques. This intervention corrects the curve, however it does not eliminate the damaged tissues. This solution causes a shortening of the penis and, in many cases, erectile dysfunction problems. However, there are improvements developed by Dr. Cruz, chief surgeon at the Andromedi Clinics in Madrid, Seville and Tenerife that reduce shortening when applying this type of treatment.
It can also be treated by iontophoresis in its initial stages, achieving good results and eliminating those fibrous bands that cause the curve.
In our centres in Madrid, Seville or the Canary Islands (Tenerife), we carry out the techniques and treatments with the most modern facilities and the best specialists and equipment to guarantee an effective solution.
A new treatment: Xiaflex
The Xiaflex, technically called “Collagenase clostridium histolyticum”, and better known as Xiapex in Europe, is manufactured and marketed by Auxilium Pharmaceuticals and Pfizer.
It was approved in 2010 by the Food and Drug Administration (FDA) for the treatment of Dupuytren-type contracture. This disease of unknown origin causes a gradual closing of the hand by retraction of the superficial palmar aponeurosis.
Since its approval for this disease, the FDA has been asked to approve it for peyronie’s disease. In fact, 30% of patients with peyronie’s disease have revealed a hardening of scar tissue in other parts of the body such as the hand or foot.
The composition of Xiapex/Xiaflex is of biological origin and is made from the protein contained in the organism “collagenase clostridium histolyticum”. Its function is to break down collagen protein.
Non-surgical peyronie treatment
Just a few days ago (December 6) Xiaflex was approved by the FDA for the treatment of peyronie's disease, becoming the first and only non-surgical treatment for this disease.
Its marketing in injectables requires, of course, a doctor’s prescription. In addition, doctors must be authorized for the application of this new drug. It is injected directly into the penis or over the affected areas. The treatment consists of four phases or cycles. Each treatment cycle includes two Xiaflex injections. A total of eight injections are given during the course of treatment.
Penis shaping (gentle stretching in the opposite direction of the deformity) is recommended after each treatment cycle to further alter the plaque. In fact, clinical trials have used this technique in conjunction with injections.
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Results
The safety and efficacy of the drug has been tested in various clinical trials conducted by BioSpecifics in collaboration with Auxilium Pharmaceuticals.
The sample used was more than 800 patients at 64 sites in the U.S. and Australia, with a 2:1 ratio of XIAFLEX versus placebo.
Patients had a penile curve of at least 30 degrees in the first two IMPRESS trials (I and II).
Xiaflex was injected twice a week every six weeks. All four treatment cycles were applied and each treatment cycle was followed by a penis modelling procedure by a specialist.
The average deformity of the penis at the beginning of the trial was 48.8 degrees and at the end of the 52 weeks it was 31.0 degrees, so the average reduction is 37.6% in penile curvature. The average reduction in the placebo group was 21.3% (49.0 degrees to 39.0 degrees). The average deformity of the penis at the start of the second round of the trial was 51.3 degrees and at the end of the 52 weeks 35.1 degrees, so the average reduction is 30.5% in penile curvature. The average reduction in the placebo group was 15.2% (from 49.6 degrees to 41.1 degrees).
How to measure a penis curve
The most reliable and long-lasting alternative for the time being is still surgery.
Palliative treatments of the acquired penis curve such as Xiaflex or iontophoresis can be very helpful in the early stages of the disease, but not very helpful when the plaques generated by Peyronie have advanced to gain consistency and size.
In these cases, surgery is the only real way to recover a satisfactory sexual life, as it reduces the deviation of the penis to a ratio of practically 0-10%. The postoperative period is not excessively annoying, and following the advice and indications of the medical team, the return to sexual normality is achieved after only one month.
In the following video you can learn more about this disease:
- VIDEO: What is and what is the treatment of Peyronie's disease or acquired curvature of the penis
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